Thrombopoietin from Hepatocytes Promotes Hematopoietic Stem Cell Regeneration after Myeloablation

Using a Thpo translational reporter, researchers found that the liver but not the bone marrow was the major source of thrombopoietin protein after myeloablation. Mice with conditional Thpo deletion from hepatocytes showed significant defects in hematopoietic stem cell regeneration and hematopoietic rebound after myeloablation.