hematopoietic stem cells

[Stem Cell Reports] The authors demonstrated that DDX41 was required for mouse HSC and progenitor cell survival and differentiation, particularly of myeloid lineage cells.

[Stem Cell Research & Therapy] Scientists produced allogeneic hematopoietic stem cell (HSC)-engineered Invariant natural killer T (iNKT) cells through TCR engineering of human cord blood CD34+ HSCs and differentiation of these HSCs into iNKT cells in an ex vivo HSC-Derived iNKT Cell Culture.

[Nature Reviews Rheumatology] Considerable advances have been made in predicting the extent and rate of skin-disease progression in diffuse cutaneous systemic sclerosis, including the development of techniques such as molecular analysis of skin biopsy samples.

[Cellular and Molecular Life Sciences] The author reviews some of the key pathways including the infectious and inflammatory processes that control hematopoiesis, followed by a comprehensive review that summarizes the latest evidence and discusses how SARS-CoV-2 infection impacts hematopoiesis.

[Blood Advances] Scientists identified CEACAM1 as a novel culture-compatible surface marker of ex vivo expanded long-term reconstituting-HSCs that further refined the immuno-phenotype of the cells.

[Cell Stem Cell] Scientists showed that loss of nuclear lamin B1 (LMNB1) encoded on chromosome 5q, which was frequently deleted in myeloid neoplasms, induced defects in nuclear morphology and human HSCs function associated with malignancy.