hematopoietic stem cells

[Molecular Therapy] Investigators treated three children suffering from severe, therapy-refractory GvHD with polyclonally expanded regulatory T cells generated from the original stem cell donor.

[Frontiers in Neurology] Investigators found that the proportions of CD19+ IL-10+ cells and CD19+CD24hiCD38hi cell subsets in myasthenia gravis patients were significantly lower than those in healthy controls.

[eLife] The authors hypothesized that the inflammatory environment of Group A Streptococcus infection drove rapid hematopoietic stem and progenitor cell (HSPC) differentiation and depletion that can be rescued by infusion of donor HSPCs.

[European Journal of Pharmacology] The authors discuss how aberrant expression of C-X-C motif chemokine 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) and CXCL12/CXCR7 pathways might regulate leukemogenesis and end by outlining the key news of preclinical and clinical investigations in leukemia treatment.

[Bone Marrow Transplantation] The authors evaluated the prevalence of key vascular complications and graft-versus-host disease among 122 pediatric patients with an allogeneic hematopoietic stem cell transplantation between 2001 and 2013.

[Haematologica] Researchers designed a CD34/CD3 bispecific T-cell engager (BiTE) and characterized its anti-leukemia potential in vitro, ex vivo and in vivo.