hepatic cells

[Cellular and Molecular Gastroenterology and Hepatology] Scientists explored the role and mechanism of spectrin beta, non-erythrocytic 1 (SPTBN1) in the autophagy of hepatic stem cells and hepatocellular carcinoma cells.

[Stem Cell Reports] Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition in human iPSCs (hiPSCs) with the use of short hairpin RNA, CRISPR/cas9-mediated knockout, or endogenous PCSK9 loss-of-function mutation R104C/V114A unveiled its new role as a potential cell cycle regulator through the NODAL signaling pathway.

[Science Advances] The authors revealed a damage-regulated autophagy modulator (DRAM)-mediated mechanism for exosome secretion and provided the foundation for plasma exosomes as a potential biomarker for nonalcoholic fatty liver disease (NAFLD).

[Scientific Reports] Scientists investigated whether pyruvate dehydrogenase complex (PDC)-E2 interacted with STAT3 in human cholangiocytes and hepatocytes under cholestatic conditions induced by glyco-chenodeoxycholic acid.

[Liver International] The effect and mechanism of AURKA on liver regeneration were studied using a 70% hepatectomy model. Human liver organoids were used as an in vitro model to investigate the effect of AURKA on hepatocyte proliferation.

[mBio] Researchers explored the roles of hepatocyte-derived exosomal microRNAs and B cell activating factor in the extrahepatic diseases of hepatitis C virus infection.