hepatic cells

[NPJ Regenerative Medicine] The authors showed that in response to extensive hepatocyte damages, expression of dnmt1 was upregulated in biliary epithelial cells (BECs) to methylate DNA at the p53 locus, which repressed p53 transcription, and in turn, derepressed mTORC1 signaling to activate BEC dedifferentiation.

[Hepatology] Scientists evaluated the function and efficacy of autologous reprogrammed, ATP7B gene-restored hepatocytes using a murine model of Wilson's disease.

[Cell Death & Disease] The inhibitory effect of Selenoprotein S (SelS) on hepatic steatosis and insulin resistance was confirmed by SelS overexpression in primary hepatocytes in vitro.

[Scientific Reports] Scientists showed that the hepatic functions of hPSC-hepatocyte-like cells were facilitated by applying physiological liver temperatures during hepatic differentiation.

[Oncogene] The authors suggested that hepatocyte nuclear factor 4 alpha antisense RNA 1 (HNF4A-AS1)-encoded small 51-amino acid peptide promoted self-renewal and aggressive features of neuroblastoma stem cells by eEF1A1-repressed SMAD family member 4 (SMAD4) transactivation.

[Scientific Reports] Investigators used selective small molecule inhibitors of monoacylglycerol acyltransferase 2 (MGAT2) and MGAT3 to determine the contributions of these enzymes to triacylglycerol production in liver cells.