hepatic cells

[Nature Communications] Scientists reported a targeted antifibrotic peptide-delivery system in which fibroblast activation protein, which was overexpressed in fibrotic regions of the liver, liberated the antifibrotic peptide melittin by cleaving a fibroblast activation protein-specific site in the peptide.

[iScience] Scientists demonstrated that syntaxin11 (STX11), a member of the SNARE family, generally expressed in immune cells, mediated lipid metabolism by binding to adipose-triglyceride-lipase (ATGL) and inhibiting lipid droplet degradation and lipid autophagy in hepatocytes.

[Journal of Cell Science] Cultured progenitor cells established from primary hepatocytes of Pkdcc knockout mice produced a secretome, which promoted their own proliferation in 3D spheroids and proliferation of cultured fibroblasts.

[Journal of Hepatology] Researchers investigated the role of X-box binding protein-1 (XBP1) in the progression of non-alcoholic steatohepatitis.

[Hepatology Communications] Researchers generated iPSC-derived hepatocytes and iPSC-derived cholangiocytes cells and characterized them based on hepatocyte-specific and cholangiocyte-specific markers.

[Birth Defects Research] To identify embryotoxic compounds, scientists developed an hiPSC-based biomarker assay based on the differentiation of hiPSCs into functional cardiomyocytes and hepatocytes.