hepatic stellate cells

[Scientific Reports] Investigators presented a 3D in vitro microtissue model that used spheroidal, scaffold free co-culture of primary human hepatocytes, Kupffer cells, liver endothelial cells and hepatic stellate cells.

[Journal of Hepatology] Investigators provide a description of several key mechanisms that contribute to lipid droplet accumulation in the hepatocytes, favouring non-alcoholic fatty liver disease (NAFLD) progression.

[iScience] Investigators implicated that glucosylceramide accumulation was one of triggers promoting the development of nonalcoholic fatty liver disease into non-alcoholic steatohepatitis, then, fibrosis and tumorigenesis.

[Life Sciences] Researchers investigated the role of survivin protein in early fibrogenic activation of hepatic stellate cells and fibrosis progression in chronic liver injury.

[Scientific Reports] Investigators found that miR-571 inhibited the apoptosis of human hepatic stellate cells and promoted cell proliferation and migration. Its up regulation promoted the expression of Notch3 and Jagged1, and promoted the expression of related fibroblasts.

[Journal of Gastroenterology and Hepatology] The autophagy attenuation exerted by chloroquine together with the reduction of the expression of the proliferation marker in hepatic stellate cells could lessen the acute liver damage, potentially opening the way to novel therapeutic approaches for hepatic fibrosis.