hepatocytes

[Stem Cell Reports] By leveraging recent knowledge of the signaling pathways involved in liver development, investigators described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.

[Scientific Reports] Researchers analyzed angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 expression and localization in human liver cancers and in non-tumor livers.

[Nature Communications] Formyl peptide receptor 2 (FPR2) was more highly expressed in hepatocytes and healthy livers from females than males, and FPR2 deletion exacerbated liver damage in choline-deficient, L-amino acid-defined, high-fat diet-fed female mice.

[Nature Metabolism] Using a candidate gene approach, researchers identified a locus at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein that reduced susceptibility to the entire spectrum of fatty liver disease in individuals at risk.

[Stem Cell Reviews and Reports] Researchers revealed that treatment with the human umbilical cord mesenchymal stromal cells significantly increased the proportion of activated primordial follicles in mouse ovaries both in vitro and in vivo.

[Nature Communications] The authors showed that mitochondrial MATα1 was selectively depleted in alcohol-associated liver disease through a mechanism that involved the isomerase PIN1 and the kinase CK2.