hepatocytes

[Hepatology] The authors performed a Sleeping Beauty transposon-based in vivo insertional mutagenesis screen in liver-specific Pten-deficient mice and identified tumor necrosis factor receptor-related factor 3 (Traf3) as the most significantly mutated gene in murine intrahepatic cholangiocarcinoma in a loss-of-function manner.

[Cell & Bioscience] Scientists investigated the role of Gm15441 in the regulation of thioredoxin-interacting protein (Txnip) and liver metabolism and found that the expression levels of Gm15441 and Txnip showed a similar response pattern to metabolic signals in vivo and in vitro, but that their functions were predicted to be opposite.

[Biomaterials Science] Researchers reported a facile and efficient strategy for in vivo tracking the secretion of hepatocyte growth factor in MSCs during idiopathic pulmonary fibrosis therapy.

[Stem Cell Research & Therapy] A type 2 diabetes mellitus (T2DM) model was established through 28-week high-fat diet feeding resulting in T2DM-associated non-alcoholic fatty liver disease, followed by the injection of bone marrow MSCs.

[Nature Communications] Hepatocyte-specific deletion of Mettl3 drove nonalcoholic fatty liver-to-NASH progression by increasing CD36-mediated hepatic free fatty acid uptake and CCL2-induced inflammation, which is due to increased chromatin accessibility in the promoter region of Cd36 and Ccl2.

[Nature Aging] Scientists showed accurate tracking of the aging process in hepatocytes, demonstrated attenuated epigenetic aging in muscle stem cells and tracked age dynamics in embryonic stem cells.