hepatocytes

[Molecular Therapy-Methods & Clinical Development] Investigators introduced NTCP-S267F variant and tested the infectivity by hepatitis B virus in genetically edited hepatic cells.

[Cancer Research] Researchers revealed that delivery of miR-122 was associated with downregulation of key genes in involved in metastatic and cancer inflammation pathways, including several pro-inflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes.

[Cell Reports] Scientists showed that Myc-driven hepatocellular carcinoma was dramatically aggravated in mice with hepatocyte-specific Ptpn11/Shp2 deletion.

[Journal of Cellular Biochemistry] Researchers examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression.

[Hepatology] Hepatitis B virus infected HepG2-NTCP were treated with tenofovir disoproxil fumarate, Toll-like receptor 7/8 agonists, TLR7/8 conditioned media collected from immune cells, or RNAi using short-interfering RNAs.

[Journal of Hepatology] Live cell imaging, histological, biochemical, and molecular studies were used to investigate the mechanisms that underlie the extracellular and intracellular action of rhMG53 in hepatoprotection.