hepatocytes

[Cell Death Discovery] Scientists defined the role of sevoflurane in hepatic ischemia-reperfusion injury as well as its underlying mechanism.

[Cell Death & Differentiation] The authors found that deficiency of Huwe1 in mice hepatocytes exacerbated ischemia-reperfusion injury and CCl4-induced liver injury with more ferroptosis occurrence, and that suppression of Huwe1 enhanced cellular sensitivity to ferroptosis in primary hepatocytes and mouse embryonic fibroblasts.

[Cell Death Discovery] Scientists presented the significant role of a novel signaling axis comprising long non-coding RNA maternally expressed gene 3 (MEG3), enhancer of zeste homolog 2 (EZH2), and sirtuin 6 (SIRT6) in controlling lipid accumulation, inflammation, and the progression of nonalcoholic fatty liver disease.

[Stem Cell Research & Therapy] MSCs were comparable to N-acetylcysteine against acetaminophen (APAP)-induced liver failure by secreting hepatocyte growth factor with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.

[Molecular Cancer Research] Scientists reported a gatekeeper function of the Ras/Erk and NF-κB pathways pathways by working in synergy to suppress liver tumorigenesis.

[Hepatology] Investigators established a hepatocyte aging model from human induced pluripotent stem cells and developed a method for ex vivo characterization of hepatocyte plasticity.