Ubiquitin Ligase E3 HUWE1/MULE Targets Transferrin Receptor for Degradation and Suppresses Ferroptosis in Acute Liver Injury

The authors found that deficiency of Huwe1 in mice hepatocytes exacerbated ischemia-reperfusion injury and CCl4-induced liver injury with more ferroptosis occurrence, and that suppression of Huwe1 enhanced cellular sensitivity to ferroptosis in primary hepatocytes and mouse embryonic fibroblasts.