Quantitative Investigation into the Influence of Intravenous Fluids on Human Immune and Cancer Cell Lines

The effect of intravenous fluids exposure on single cells was characterized using hemocytometer, fluorescence microscopy and flow cytometry
[Scientific Reports]
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The Intraprostatic Immune Environment after Stereotactic Body Radiotherapy Is Dominated by Myeloid Cells

Freshly resected prostate specimens were processed to obtain single-cell suspensions, and immune-phenotyped for major lymphoid and myeloid cell subsets by staining with two separate 14-antibody panels and multicolor flow cytometry analysis.
[Prostate Cancer and Prostatic Diseases]
Nickols, N. G., Ganapathy, E., Nguyen, C., Kane, N., Lin, L., Diaz-Perez, S., … Schaue, D. (2020). The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells. Prostate Cancer and Prostatic Diseases, 1–5. https://doi.org/10.1038/s41391-020-0249-8 Cite
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Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function.
[Frontiers in Immunology]
Junker, F., Gordon, J., & Qureshi, O. (2020). Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01393 Cite
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Immunotherapies and Metastatic Cancers: Understanding Utility and Predictivity of Human Immune Cell Engrafted Mice in Preclinical Drug Development

Pre-clinical immuno-oncology models for studying metastases have long been limited to syngeneic or carcinogenesis-inducible models that have murine cancer and immune cells.
[Cancers]
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The Cancer–Natural Killer Cell Immunity Cycle

Investigators discuss how the role of NK cells evolves with tumor progression, presenting new opportunities to target NK cell function to enhance cancer immunotherapy response rates across a more diverse range of cancers.
[Nature Reviews Cancer]
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Thymic Development of Unconventional T Cells: How NKT Cells, MAIT Cells and γδ T Cells Emerge

Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology]
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Clinical Relevance of B7H3 Expression in Retinoblastoma

Scientists validated the previous finding by Western blotting and immunohistochemistry on primary retinoblastoma (RB) tumor samples. The results suggested significantly increased expression of B7H3 in RB tumor samples compared to retina by western blotting.
[Scientific Reports]
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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]
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Tumor-Induced Neurogenesis and Immune Evasion as Targets of Innovative Anti-Cancer Therapies

The authors discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy]
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Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for cytokine release syndrome, which is a common cause of adverse clinical outcomes in COVID-19.
[Trends in Pharmacological Sciences]
Luo, W., Li, Y.-X., Jiang, L.-J., Chen, Q., Wang, T., & Ye, D.-W. (2020). Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19. Trends in Pharmacological Sciences, 0(0). https://doi.org/10.1016/j.tips.2020.06.007 Cite
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UCLA Receives Nearly $14 Million from NIH to Investigate Gene Therapy to Combat HIV

University of California, Lost Angeles (UCLA) researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
[Univesity of California, Los Angeles]
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