Immune Regulation News

[Scientific Reports] Histones were rapidly lethal to neutrophils after binding to cells, but formation of fibrinogen/fibrin-histone aggregates prevented cell death.

[Cellular & Molecular Immunology] Investigators observed that CFTR was functionally expressed on the cell surface of γδ T cells. Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γ release by peripheral γδ T cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.

[Frontiers in Immunology] Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.

[Immunity] The authors review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.