CFTR Is a Negative Regulator of γδ T Cell IFN-γ Production and Antitumor Immunity

Investigators observed that CFTR was functionally expressed on the cell surface of γδ T cells. Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γ release by peripheral γδ T cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.