Fibrinogen Protects Neutrophils from the Cytotoxic Effects of Histones and Delays Neutrophil Extracellular Trap Formation Induced by Ionomycin

Histones were rapidly lethal to neutrophils after binding to cells, but formation of fibrinogen/fibrin-histone aggregates prevented cell death.
[Scientific Reports]
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CFTR Is a Negative Regulator of γδ T Cell IFN-γ Production and Antitumor Immunity

Investigators observed that CFTR was functionally expressed on the cell surface of γδ T cells. Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γ release by peripheral γδ T cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.
[Cellular & Molecular Immunology]
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Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function.
[Frontiers in Immunology]
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Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis

Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]
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Determinants of Resident Tissue Macrophage Identity and Function

The authors review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
[Immunity]
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Nanoparticle Delivery of Immunostimulatory Oligonucleotides Enhances Response to Checkpoint Inhibitor Therapeutics

Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.
[Proceedings of the National Academy of Sciences of the United States of America]
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DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.
[Nature]
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A Variant in IL6ST with a Selective IL-11 Signaling Defect in Human and Mouse

Researchers characterized the impact of a variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and supported these findings using a mouse model with the corresponding genome-edited variant Il6st p.R279Q.
[Bone Research]
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convertibleCARs: A Chimeric Antigen Receptor System for Flexible Control of Activity and Antigen Targeting

An inert form of the human NKG2D extracellular domain (iNKG2D) was engineered as the ectodomain of the chimeric antigen receptor (CAR) to generate convertibleCARTM-T cells. These cells were specifically directed to kill antigen-expressing target cells only in the presence of an activating bispecific adapter comprised of an iNKG2D-exclusive ULBP2-based ligand fused to an antigen-targeting antibody
[Communications Biology]
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
[Cell]
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Old Dogs, New Trick: Classic Cancer Therapies Activate cGAS

The authors review the antitumor roles of the GMP-AMP synthase (cGAS-STING) pathway during tumorigenesis, cancer immune surveillance, and cancer therapies. They also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation.
[Cell Research]
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