in silico

[Journal of Immunology] Scientists showed that IL-22+ T cells coexpressing retinoic acid–related orphan receptor γt were enriched at the human maternal-fetal interface of women with preterm labor and birth, which was confirmed by in silico analysis of single-cell RNA sequencing data.

[Acta Pharmacologica Sinica] Alcohol dehydrogenase 1C (ADH1C) was first identified as a target gene closely associated with the development of CRC by the comprehensive application of transcriptomics, proteomics, metabonomics and in silico analysis.

[Genomics] Investigators elucidated an important role of PIEZO1 in breast cancer and provided key clues for identifying PIEZO1 as a therapeutic target and prognostic biomarker in breast cancer.

[Bioorganic Chemistry] Investigators evaluated the ability of pigment C-phycocyanin to bind to the main cellular targets related in the progression of melanoma through molecular docking, and the reflection of this bind in the biological effects in the B16F10 cell line through in vitro analysis.

[European Journal of Human Genetics] Investigators discovered an increased allelic expression pattern accompanied with overexpression of human leucocyte antigen (HLA)-B gene in SARS-CoV-2-infected human lung epithelial cells.

[Cell Death & Disease] YTHDF1 facilitated S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitized breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor.