in silico

[Journal of Neuro-Oncology] Scientists isolated extracellular vesicles from medulloblastoma and diffuse infiltrative pontine glioma patient-derived cell lines and explored the small ncRNA transcriptome.

[Cancer Letters] Investigators validated the therapeutic efficacy the FDA-approved FGFR inhibitor pemigatinib, in an integrated platform consisting of human and murine prostate cancer (PCa) cells, and the transgenic multistage TRAMP model of PCa that recapitulated both androgen-dependent and CRPC settings.

[Communications Biology] In iPSC-derived retinal pigment epithelium from late-onset retinal degeneration patients, researchers showed that the dominant pathogenic CTRP5 variant led to reduced CTRP5 secretion.

[Scientific Reports] Cabazitaxel (CBZ) was approved for the treatment of docetaxel-resistant castration-resistant prostate cancer (CRPC). Researchers explored the optimal treatment for CRPC in the post-cabazitaxel setting using PC3 (CBZ-sensitive) and PC3CR cells (CBZ-resistant).

[Medical Oncology] Scientists investigated the effect of resveratrol and BIBR1532, either alone or in combination, on the cell viability as well as on expression of long non-coding RNAs for HT-29 colon adenocarcinoma cells.

[Febs Letters] The authors review the current knowledge of fibroblast interactions in the healthy, diseased and aging heart.