in silico

[Cell Death Discovery] The authors screened various collagen types and observed that the type V collagen α1 chain (COL5A1) gene played a pivotal role in glioblastoma. They investigated the involvement of COL5A1 in ECM remodeling and the regulation of actin filaments in the metastasis of GBM.

[International Immunopharmacology] Scientists investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.

[Molecular & Cellular Proteomics] Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.

[Biomed Research International] Peripheral blood and endometrial (e)MSC specimens were collected from suspected women of endometriosis before laparoscopy. Total RNA was isolated from plasma and cultured eMSCs to synthesize complementary DNA.

[Nature Medicine] The authors investigated a clinically annotated pediatric myelodysplastic syndromes cohort to define the prevalence, genetic landscape, phenotype, therapy outcome and clonal architecture of SAMD9/9L syndromes.

[Acta Pharmaceutica Sinica B] Scientists demonstrated that physapubenolide (PB) inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis. They explored the mechanism underlying the anticancer effects of PB through an in silico target prediction study.