induced pluripotent stem cells

[Scientific Reports] Scientists established various human cell lines with human artificial chromosomes/mouse artificial chromosomes that harbored a gene-loading site via microcell-mediated chromosome transfer.

[Cell Stem Cell] Researchers showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human PSC-derived midbrain dopamine (mDA) neurons, recapitulated brain-wide mDA target innervation.

[Cell Death Discovery] Scientists reported the characteristics and function of mitochondria during human definitive endoderm differentiation.

[Nature Aging] To elucidate the polygenic architecture of Alzheimer’s disease (AD) phenotypes at a cellular level, the authors established iPSCs from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ).

[Communications Biology] Researchers developed a tool, named BrewerIX, that provided comprehensive information about the allelic expression of a large, manually-curated set of imprinted and X-linked genes.

[Science Advances] Investigators developed a system for the production of platelet precursor cells, megakaryocytes, from PSCs. These cultures could be maintained for greater than 100 days, implying culture renewal by megakaryocyte progenitors.