Dissection of the Polygenic Architecture of Neuronal Aβ Production Using a Large Sample of Individual iPSC Lines Derived from Alzheimer’s Disease Patients

To elucidate the polygenic architecture of Alzheimer’s disease (AD) phenotypes at a cellular level, the authors established iPSCs from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ).