induced pluripotent stem cells

[Stem Cell Reports] The authors used Duchenne muscular dystrophy-patient-specific human iPSCs to model cardiomyopathic features and unravel novel pathologic insights.

[Nature Communications] Researchers characterized the expression pattern and examined the function of Lima1 in mouse embryos and PSC lines.

[Molecular Therapy-Methods & Clinical Development] Scientists inserted iCasp9 gene into the endogenous OCT4 locus of human and mouse PSCs without affecting their pluripotency. A chemical inducer of dimerization, AP1903, induced iCasp9 activation, which led to the apoptosis of specific undifferentiated PSCs in vitro and in vivo.

[Stem Cell Research] Researchers reprogrammed CD34+-umbilical cord blood cells with the group O/D-negative blood type as a universal source for red blood cell generation.

[Circulation] The authors comprehensively phenotyped human PSC-cardiomyocytes after in vitro maturation for 20 and 40 days on either polydimethylsiloxaneor standard tissue culture plastic substrates.

[Cell Stem Cell] Investigators showed strong, graded, repetitive, and wavelength-specific light-evoked responses from retinal organoid cones.