induced pluripotent stem cells

[Stem Cell Reports] By employing their recently developed retina on chip that merged organoid and organ-on-chip technology, scientists analyzed the efficacy, kinetics, and cell tropism of seven first- and second-generation adeno-associated virus (AAV) vectors.

[Advanced Materials] The authors used viscoelastic alginate hydrogels with independently tunable stress relaxation, stiffness, and arginine–glycine–aspartate ligand density to study human iPSC morphogenesis in 3D culture.

[Stem Cell Reports] The authors developed a robust multi-cell type 3D vessel-on-chip model based entirely on human induced pluripotent stem cells (hiPSCs). Within a fibrin hydrogel microenvironment, the hiPSC-derived vascular cells self-organized to form stable microvascular networks reproducibly, in which the vessels were lumenized and functional, responding as expected to vasoactive stimulation.

[Journal of Cellular and Molecular Medicine] Investigators established a simple method to convert human pluripotent stem cells into skeletal muscle cells by using temperature-sensitive Sendai virus vector encoding myoblast determination protein , a myogenic master transcription factor.

[Trends in Genetics] Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs). Investigators summarize recent progress and new strategies in deciphering pathogenic variants for CVDs using CRISPR-edited human iPSCs.

[Stem Cell Reports] Investigators used a porcine model to provide proof-of-concept evidence that a combination of amiodarone and ivabradine could effectively suppress engraftment arrhythmia.