induced pluripotent stem cells

[ACS Biomaterials Science & Engineering] Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers described an optimized protocol to differentiate human iPSCs to a late myogenic stage, allowing them to recapitulate classical Duchenne muscular dystrophy (DMD) phenotypes in isogenic DMD-mutant iPSC lines in vitro.

[ExCellThera, Inc.] ExCellThera, Inc. announced that it has entered into a licensing agreement with Astellas Pharma, Inc. through its US subsidiary, Astellas Institute for Regenerative Medicine, for the in vitro use of the UM171 compound and certain other molecules in the field of PSCs and PSC-derived cells.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that gene-edited, immune-evasive cell grafts could survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas.

[Tissue Engineering Part B-Reviews] The authors discuss the various stem cell types identified in rodent and human hair follicles and ongoing studies on the potential use of hair follicle stem cells for skin, bone, cardio-vascular, and nerve tissue engineering.

[Cell and Tissue Research] Scientists explored whether human-induced pluripotent stem cells could represent unlimited cell sources for neo-cartilage comparable to human primary articular chondrocytes or human bone marrow-derived MSCs.