induced pluripotent stem cells

[Molecular Therapy] Researchers applied adenine base editors to correct the Z mutation in patient-induced pluripotent stem cells (iPSCs) and iPSC-derived hepatocytes.

[Stem Cell Reports] Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.

[Science Translational Medicine] Researchers combined human iPSCs and airway-on-a-chip technology to demonstrate the effectiveness of fluid shear stress for regulating the global axis of multicellular planar cell polarity, as well as inducing ciliogenesis, thereby contributing to quantifiable unidirectional mucociliary flow.

[Stem Cell Reports] Scientists proposed a novel strategy to generate hindbrain serotonin (5-HT) neurons from human PSCs, which involved the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development.

[Nature Biomedical Engineering] Researchers reported the single-cell characterization of the differentiation of pancreatic duct-like organoids from human induced pluripotent stem cells (hiPSCs) on a microwell chip that facilitated the uniform aggregation and chemical induction of hiPSC-derived pancreatic progenitors.

[Biochimica et Biophysica Acta-Reviews On Cancer] Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. The authors describe both normal and CRC intestinal organoid models and their utility in the cancer research field.