induced pluripotent stem cells

[Cell Death & Disease] Scientists optimized a protocol to generate chemically defined human induced pluripotent stem cell-derived mesodermal progenitors and they demonstrate that these cells contributed to myotube formation and differentiated into cardiomyocyte.

[Scientific Reports] Researchers revealed that angiopoietins, including angiopoietin-1 and angiopoietin-2 permitted the generation of islets from iPSCs with elevated glucose responsiveness, a hallmark of mature islets.

[Scientific Reports] Variants of CD33 were associated with Alzheimer’s disease (AD) suggesting that modulation of CD33 signaling might be beneficial in AD. Scientists developed a reliable cellular CD33 reporter systems.

[Nature Reviews Urology] Over the past two decades, substantial advances have been made in the identification of Leydig cell sources for use in transplantation surgery, including the artificial induction of Leydig-like cells from different types of stem cells, for example, stem Leydig cells, mesenchymal stem cells, and pluripotent stem cells.

[Experimental Cell Research] The authors characterized the cellular expression and localization patterns of pyruvate kinase muscle isoforms in mouse ESCs, chemically transitioned epiblast-like cells (mEpiLCs) representing formative pluripotency, and mEpiSCs using immunoblotting and confocal microscopy.

[Communications Biology] Investigators demonstrated conditions for in vitro reconstitution of a testicular environment from ESCs and provided further insights into the generation of sperm entirely in xeno-free culture.