innate lymphoid cells

[Science] Investigators assessed the impact of a time-restricted enterobacterial challenge to long-term type 3 innate lymphoid cells (ILC3) activation in mice.

[Proceedings of the National Academy of Sciences of the United States of America] In the absence of IFN-γ, lung innate lymphoid cells (ILC12) from mice challenged with the A/California/04/2009 H1N1 virus, containing nonfunctional viral PB1-F2, initiated a robust IL-5 response, which also led to improved tissue integrity and increased survival.

[Cancer Cell] The authors showed that oncogenic KrasG12D increased IL-33 expression in PDAC cells, which recruited and activated TH2 and innate lymphoid cells 2 cells.

[Nature Immunology] Scientists found that CCR6+ type 3 innate lymphoid cells could trigger an increase in the number of T cells infiltrating a tumor.

[European Journal of Pharmacology] Transient receptor potential vanilloid 2 (TRPV2) may represent a novel biomarker for asthma in children; meanwhile, TRPV1 and TRPV4 seem to be essential contributors to the development and exacerbations of asthma.

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.