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innate lymphoid cells

Trained ILC3 Responses Promote Intestinal Defense

[Science] Investigators assessed the impact of a time-restricted enterobacterial challenge to long-term type 3 innate lymphoid cells (ILC3) activation in mice.

Viral PB1-F2 and Host IFN-γ Guide ILC2 and T Cell Activity during Influenza Virus Infection

[Proceedings of the National Academy of Sciences of the United States of America] In the absence of IFN-γ, lung innate lymphoid cells (ILC12) from mice challenged with the A/California/04/2009 H1N1 virus, containing nonfunctional viral PB1-F2, initiated a robust IL-5 response, which also led to improved tissue integrity and increased survival.

Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer

[Cancer Cell] The authors showed that oncogenic KrasG12D increased IL-33 expression in PDAC cells, which recruited and activated TH2 and innate lymphoid cells 2 cells.

Recruitment and Activation of Type 3 Innate Lymphoid Cells Promote Antitumor Immune Responses

[Nature Immunology] Scientists found that CCR6+ type 3 innate lymphoid cells could trigger an increase in the number of T cells infiltrating a tumor.

Transient Receptor Potential Cation Channel Subfamily V (TRPV) and Its Importance in Asthma.

[European Journal of Pharmacology] Transient receptor potential vanilloid 2 (TRPV2) may represent a novel biomarker for asthma in children; meanwhile, TRPV1 and TRPV4 seem to be essential contributors to the development and exacerbations of asthma.

Early-Life Imprinting of Unconventional T Cells and Tissue Homeostasis

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.

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