innate lymphoid cells

[Journal For Immunotherapy of Cancer] Human and murine breast CSCs were tested for their production of and response to IL30 by using flow cytometry, confocal microscopy, proliferation and sphere-formation assays, and PCR array.

[Clinical Cancer Research] Investigators combined radiation, immunotherapies, genetic mouse models, and antibody depletion experiments to identify the role of NK cells in overcoming resistance to radiation therapy in orthotopic models of head and neck squamous cell carcinoma

[Hepatology] Investigators found high expression of RORα in liver-resident NK cells/ILC1s. Mice with conditional ablation of Rora in LrNK cells/ILC1s and conventional NK (cNK) cells had decreased LrNK cells/ILC1s but normal numbers of cNK cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that mutant keratinocytes (KC) clone size was markedly reduced in the absence of RORγt+ lymphocytes or interleukin (IL)-22, both observed in association with expanding KC clones, and found that topical application of a RORγ/γt inhibitor during chronic ultraviolet (UV) exposure reduced local expression of IL-22 and IL-17A while markedly limiting mutant p53 KC clonal expansion.

[Cell Metabolism] Investigators defined alterations in the adipose-resident immune system and identify that type 2 innate lymphoid cells (ILC2s) were lost in aging.

[Nature Immunology] Through multiplexed single-cell mRNA sequencing, the authors identified cKit+CD127hiTCF-1hi early differentiation stages of T-bet+ innate lymphoid cells.