Scientists showed that mutant keratinocytes (KC) clone size was markedly reduced in the absence of RORγt+ lymphocytes or interleukin (IL)-22, both observed in association with expanding KC clones, and found that topical application of a RORγ/γt inhibitor during chronic ultraviolet (UV) exposure reduced local expression of IL-22 and IL-17A while markedly limiting mutant p53 KC clonal expansion.
[Proceedings of the National Academy of Sciences of the United States of America]