innate lymphoid cells

[Experimental & Molecular Medicine] Scientists review the current evidence of type II innate lymphoid cells (ILC2)-mediated modulation of neuroinflammatory cues within the central nervous system (CNS), highlight the distribution of ILC2s in both the periphery and CNS, and discuss some challenges associated with cell type-specific targeting that are important for therapeutics.

[Journal of Experimental Medicine] Investigators developed new transgenic mice to profile pulmonary GM-CSF expression, which they detected in both immune cells, including group 2 innate lymphoid cells and γδ T cells, as well as AT2s.

[Cell] Scientists identified that colorectal cancer manifested with altered ILC3s that were characterized by reduced frequencies, increased plasticity, and an imbalance with T cells.

[Mucosal Immunology] Through transcriptomics analysis, we observed that Entamoeba histolytica infection was associated with increased expression of IL-33 mRNA in both the human and murine colon.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that the differentiation of innate lymphoid cells (ILC2s), and their concomitant high level of GATA3 expression, were controlled by a Gata3 enhancer, Gata3 +674/762, that plays only a minimal role in T helper type 2 cell differentiation.

[Mucosal Immunology] Using mice specifically defective for either mTORC1 or mTORC2 in ILC3s, scientists show that both mTOR complexes regulate the maintenance of type III Innate lymphoid cells at steady state and pathological immune response during colitis.