insulin

[Trends in Endocrinology and Metabolism] The authors highlight the importance of studying pancreatic β-cell expansion and functional maturation signaling pathways and epigenetic programs to understand the causes of different forms of diabetes and to permit the design of novel therapeutic strategies.

[Molecular and Cellular Biochemistry] The authors focuse on a deeper understanding of the possible role of proliferator-activated receptor γ (PPARγ) in the pathogenesis of psoriasis and the potential of PPARγ agonist to improve the treatment of psoriasis.

[Nature] Scientist sequenced the DNA of cutaneous and acral melanomas from a large cohort of human patients and found a specific enrichment for BRAF mutations in cutaneous melanoma and enrichment for CRKL amplifications in acral melanoma.

[Molecular Psychiatry] Researchers performed the largest transcriptome-wide association study for postpartum depressionto date using RNA-sequencing in whole blood and deconvoluted cell types.

[Science Translational Medicine] In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented improved stimulation index of glucose-induced insulin secretion.

[Trends in Neurosciences] The authors summarize key roles of insulin action in the brain and how this involves different brain cell types.