insulin

[Scientific Reports] Researchers elucidated the effects of dipeptidyl peptidase-4 inhibitor and/or sodium-glucose co-transporter 2 inhibitor on β-cell mass and function and compared their effects between in an early and advanced phase of diabetes.

[Journal of Molecular Medicine] Scientists showed that proteomic analyses of pancreas tissue from non-obese diabetic (NOD) mice suggested that FhHDM-1 activated the PI3K/Akt signalling pathway, which was associated with β-cell metabolism, survival and proliferation.

[Platelets] Scientists showed that Kv1.3-deficient platelets displayed enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin αIIb.

[Nature Protocols] Investigators detailed a six-stage planar differentiation methodology for generating human pluripotent stem cell–derived pancreatic β cells that secreted high amounts of insulin in response to glucose stimulation.

[Nature Aging] The authors found that senescent cells inhibited vascular smooth muscle cells (VSMCs) promigratory phenotype switching in the first interfiber space of the arterial wall directly beneath the atherosclerotic plaque, thereby limiting lesion entry of medial VSMCs for fibrous cap assembly or reinforcement.

[Scientific Reports] Investigators made use of a clonal beta cell line (1.1B4) available from the European Collection of Authenticated Cell Cultures, which had been generated by the fusion of primary human beta-cells with a pancreatic ductal carcinoma cell, PANC-1.