insulin

[Journal of Physiology] Muscle specific deletion of β-catenin induced in adult mice impaired both exercise and contraction (isolated muscle) induced glucose uptake without affecting running performance or canonical exercise signaling pathways.

[Adocia, Inc.] Adocia, Inc. announced the launch of a Phase I clinical study in collaboration with Dr. Ahmad Haidar, McGill University, Canada, to assess pharmacokinetic, glycemic control and safety of BioChaperone® Lispro Pramlintide prandial formulation in 16 people with type I diabetes compared to rapid insulin lispro.

[Cell Reports] Researchers established that hepatocyte depolarization depressed hepatic afferent vagal nerve firing, increased GABA release from liver slices, and caused hyperinsulinemia.

[Endocrine Connections] Gestating and non-gestating mice were used to evaluate the in vivo effect of oxytocin signal on β-cells during pregnancy. In vitro experiments were performed on INS-1 insulinoma cells.

[Nature Metabolism] Scientists conducted a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum, from normoglycemia to type 2 diabetes.

[Science Signaling] Scientists used a temporally restricted model of hepatic repair in which large-scale hepatocyte injury and regeneration were initiated through the acute loss of Mdm2 in hepatocytes, resulting in the rapid, coordinated proliferation of biliary epithelial cells.