Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release

By
Justin.choi
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Researchers established that hepatocyte depolarization depressed hepatic afferent vagal nerve firing, increased GABA release from liver slices, and caused hyperinsulinemia.
[Cell Reports]
Geisler, C. E., Ghimire, S., Hepler, C., Miller, K. E., Bruggink, S. M., Kentch, K. P., Higgins, M. R., Banek, C. T., Yoshino, J., Klein, S., & Renquist, B. J. (2021). Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release. Cell Reports, 35(13). https://doi.org/10.1016/j.celrep.2021.109298 Cite
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