insulin

[Molecular Medicine Reports] The authors investigated the role of sigma‑1 receptor (Sig-1R) in islet β‑cell proliferation and examined the effects of Sig‑1R on islet β‑cell injury under lipotoxic conditions.

[Oramed Pharmaceuticals, Inc.] Oramed Pharmaceuticals, Inc. announced it has completed enrollment of all patients in a Phase II trial of its oral insulin capsule ORMD-0801 for the treatment of non-alcoholic steatohepatitis (NASH).

[Nature Communications] Scientists explored the effect of Autophagy-related 5 (Atg5) deficiency in liver CD11c+ cells in mice fed HFD. When compared to control mice, Atg5-deficient CD11c+ mice exhibit increased glucose intolerance and decreased insulin sensitivity when fed HFD.

[Nature Communications] The authors demonstrated that both therapeutic and preventative IL-23 blockade alleviated glucose intolerance, insulin resistance and protects against non-alcoholic fatty liver diseasedevelopment.

[Metabolic Brain Disease] The authors review the mechanisms by which a reactive gliosis can induce or contribute to the development and progression of Alzheimer’s disease.

[Nature Communications] Scientists studied the role of lysosomal Ca2+ in transcription Factor EB (TFEB) activation by mitochondrial or metabolic stress and that of TFEB-mediated mitophagy in pancreatic β-cell function.