Lysosomal Ca²⁺-Mediated TFEB Activation Modulates Mitophagy and Functional Adaptation of Pancreatic β-Cells to Metabolic Stress

Scientists studied the role of lysosomal Ca2+ in transcription Factor EB (TFEB) activation by mitochondrial or metabolic stress and that of TFEB-mediated mitophagy in pancreatic β-cell function.