intestinal cells

[Nature] Scientists showed that dietary fructose improved the survival of intestinal cells and increased intestinal villus length in several mouse models.

[Mucosal Immunology] A combination of genetic and genomic approaches were used to define a critical role of IEC-intrinsic negative elongation factor (NELF) complex in maintenance of epithelial homeostasis.

[Nature Immunology] Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.

[Oncogene] Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.

[Molecular Metabolism] Human duodenal organoids were CRISPR-Cas9 modified to express the fluorescent protein Venus or the Ca2+ sensor GCaMP7s under control of the endogenous motilin promoter.

[Cell Death & Disease] Researchers showed that ERp29 was a novel target for microRNA-135a-5p to inhibit the progression of colorectal cancer (CRC); correspondingly, ERp29 acted as an oncoprotein in CRC by promoting proliferation and metastasis of CRC cells, and suppressing apoptosis of the cells.