intestinal cells

[Cell Death & Disease] Scientists investigated the function of argininosuccinate synthetase (ASS1) in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients.

[Proceedings of the National Academy of Sciences of the United States of America] The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.

[Journal of Experimental Medicine] Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confered barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.

[Cell Death & Disease] Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.

[Science Immunology] To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.

[Nature Communications] Scientists performed an integrative genomic profiling of 163 pediatric liver tumors based on the data acquired from a cohort study. DNA methylation profiling revealed that classical hepatoblastomas were characterized by the specific hypomethylated enhancers, which were enriched with binding sites for ASCL2, a regulatory transcription factor for definitive endoderm in Wnt-pathway.