TNF-α Synergises with IFN-γ to Induce Caspase-8-JAK1/2-STAT1-Dependent Death of Intestinal Epithelial Cells

Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.