intestinal cells

[mBio] Investigators developed a method for live-cell imaging of microbial infection dynamics on human adult stem cell-derived intestinal epithelial cell layers.

[Immunity] The authors used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut.

[Journal of Clinical Investigation] Researchers showed that TNF-independent intestinal epithelial cells death after A20 and Abin-1 deletion was rescued by germ-free derivation or deletion of MyD88, while deletion of Trif provided only partial protection.

[Oncogene] The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.

[Oncogene] BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.

[Cell Reports] Investigators developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.