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intestinal epithelial cells

Dietary Suppression of MHC Class II Expression in Intestinal Epithelial Cells Enhances Intestinal Tumorigenesis

[Cell Stem Cell] Researchers showed that a high-fat diet reduced the expression of the major histocompatibility complex class II genes in intestinal epithelial cells, including intestinal stem cells.

Deoxycholic Acid Delays the Wound Healing of Colonic Epithelial Cells via Transmembrane G-Protein-Coupled Receptor 5

[Journal of Gastroenterology and Hepatology] Researchers investigated the role of transmembrane G-protein-coupled receptor in wound healing in the context of colonic epithelial cells in the presence of bile acids.

Human Small Intestinal Infection by SARS-CoV-2 Is Characterized by a Mucosal Infiltration with Activated CD8+ T Cells

[Mucosal Immunology] Researchers indicated that intraepithelial CD8+ T cells were activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19.

Therapeutic Targeting of Endoplasmic Reticulum Stress in Acute Graft-versus-Host Disease

[Haematologica] Scientists showed that endoplasmic reticulum stress contributed to intestinal tissue injury during graft-versus-host disease and could be targeted pharmacologically.

Characterization of an In Vitro 3D Intestinal Organoid Model by Using Massive RNAseq-Based Transcriptome Profiling

[Scientific Reports] Investigators show a comprehensive transcriptome-wide characterization of mouse gut organoids derived from different intestinal compartments and from mice of different gender and age.

Recombinant Soluble Thrombomodulin Accelerates Epithelial Stem Cell Proliferation in Mouse Intestinal Organoids and Promotes the Mucosal Healing in Colitis

[Clinical Gastroenterology and Hepatology] Mouse intestinal organoids and dextran sulfate sodium-induced colitis mouse model were used to assess the effects of recombinant soluble thrombomodulin on proliferation of intestinal epithelial cells.

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