islets

[Advanced Science] Investigators developed a new microfluidic multi-organoid system that recapitulated the human liver-pancreatic islet axis in normal and disease states.

[Weill Cornell Medicine] Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.

[Journal of Environmental Sciences] In a cell-based in vitro bioassay, scientists used mouse β-TC-6 cancer cells and found 48-hour exposure to perfluorooctane sulfonate (PFOS) decreased the cell viability at 50 μmol/L. By measuring insulin content in supernatant, 48-hour pretreatment of PFOS (100 μmol/L) decreased the insulin release capacity of β-TC-6 cells after glucose stimulation.

[Cell Death Discovery] Synaptotagmin-8 (SYT8) is a membrane protein that regulates hormone secretion and neurotransmission, and its expression is positively regulated by the promoter of the insulin gene in pancreatic islet cells. Researchers identified a previously unknown role of SYT8 in altering tumor characteristics in pancreatic cancer.

[Peptides] Investigators describe mechanisms involved in insulin secretion as well as metabolic and mitogenic actions on its target tissues.

[Journal of Biological Chemistry] Researchers reported that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors, thereby conferring to rat islets their competence to exhibit first phase glucose-stimulated insulin secretion.