islets

[Journal of Nutritional Biochemistry] Researchers investigated the short-term effect of 1α,25(OH)2 vitamin D3 and cholecalciferol on the glycemia and insulin sensitivity of control and dexamethasone-induced insulin-resistance in rats.

[Laboratory Investigation] ATP synthase inhibitory factor subunit 1 (IF1) is a mitochondrial protein interacting with ATP synthase to inhibit its enzyme activity. Scientists investigated islets freshly isolated from mouse lines with global inhibitory factor subunit 1 knockout (IF1−/−) and overexpression.

[Journal of Nutritional Biochemistry] Researchers explored the underlying mechanisms of type 2 diabetes prevention by vitamin D, concentrating on pancreatic iron deposition reported recently.

[Journal of Diabetes investigation] Recent research has suggested that transdifferentiation and dedifferentiation are involved in the decrease in β-cell volume and that it may change dynamically depending on the glucose metabolic state.

[Acta Physiologica] Given the ability of SARS-COV-2 to infect human pluripotent stem cell-derived pancreatic cells in vitro and the presence of SARS-CoV-2 in pancreatic samples from COVID-19 patients strongly hints that SARS-CoV-2 can invade the pancreas and directly cause pancreatic injury and diabetes.

[Frontiers in Immunology] Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.