islets

[Biomedicine & Pharmacotherapy] The authors highlight the interactions between mesenchymal stem cells (MSCs) and different immune cells to mediate immunomodulatory functions along with the importance of MSCs therapy for the successful islet transplantation.

[Cell Reports] Scientists used genetic engineering to create human PSCs in which the majority of the polymorphic human leukocyte antigens, the main drivers of allogeneic rejection, were deleted.

[Orizuru Therapeutics, Inc.] Orizuru Therapeutics, Inc. (OZTx) announced the launch of its operations. OZTx is a research and development-driven company focusing on the development of iPSC-based regenerative medicine and the application of iPSC technology.

[Nature Materials] Human IPSCs-L1 were differentiated to islet organoids and labeled with superparamagnetic iron oxide nanoparticles. The phantoms comprising of different numbers of labeled islet organoids were imaged using an magnetic particle imaging system.

[Stem Cells Translational Medicine] Scientists discuss the potential of both stem cell-derived pancreatic progenitors and more matured insulin-producing cells to treat diabetes.

[Nature Communications] Scientists reported that large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, was activated under diabetic conditions and induced β-cell apoptosis and impaired function.