islets

[Cell Metabolism] Researchers describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19.

[Communications Biology] Researchers used phasor - Fluorescence Lifetime Imaging Microscopy to monitor oxidative phosphorylation and glycolysis in living islet cells before and after glucose stimulation.

[Molecular Metabolism] The aims are not to discuss specificities of pathways controlling secretion but to compare qualitative and quantitative features of glucose-induced insulin secretion in isolated human islets and in living human subjects.

[Cell Metabolism] Researchers found that the SARS-CoV-2 receptor, ACE2 and related entry factors were expressed in β-cells, with selectively high expression of NRP1.

[Cell Death & Disease] RNA-sequencing analysis showed a comprehensive downregulation of β cell and α cell identity genes in A-485-treated islets, without upregulation of dedifferentiation markers and derepression of disallowed genes.

[Glycobiology] Investigators applied a glycoproteomic approach to identify proteoglycans, their glycosaminoglycan chains and their attachment sites in insulin-secreting cells.