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Pulmonary Cell NewsRNA-sequencing analysis showed a comprehensive downregulation of β cell and α cell identity genes in A-485-treated islets, without upregulation of dedifferentiation markers and derepression of disallowed genes.
[Cell Death & Disease]
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Zhang, L., Sheng, C., Zhou, F., Zhu, K., Wang, S., Liu, Q., Yuan, M., Xu, Z., Liu, Y., Lu, J., Liu, J., Zhou, L., & Wang, X. (2021). CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity. Cell Death & Disease, 12(5), 1–12. https://doi.org/10.1038/s41419-021-03761-1 Cite
