keratinocytes

[Journal of Investigative Dermatology] Investigators confirmed that the rosacea-like skin inflammation induced by Cathelicidin LL37 was alleviated in aged mice and mice with progeria.

[Microscopy Research and Technique] Investigators used an organotypic model of wound healing and we seeded keratinocytes on a adipose-derived MSC-induced dermal matrix. Conventional hematoxylin–eosin stain and immunohistochemistry staining for Ki67, p63 and pan-keratins were performed at different timepoints.

[Molecular and Cellular Biochemistry] The authors focuse on a deeper understanding of the possible role of proliferator-activated receptor γ (PPARγ) in the pathogenesis of psoriasis and the potential of PPARγ agonist to improve the treatment of psoriasis.

[Photochemistry and Photobiology] Though nobiletin limited UVB-irradiated human keratinocytes from undergoing cell death, researchers found that this enhanced survival was not associated with increased nucleotide excision repair or XPA expression. Instead, nobiletin reduced initial UV photoproduct formation and promoted a G1 cell cycle arrest.

[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.

[Journal of Nanobiotechnology] A nanocomposite-based hydrogel was constructed by loading methotrexate into ZnO/Ag to realize combined multiple target therapy of psoriasis.