keratinocytes

[Toxicology in Vitro] Investigators evaluated the effects of electronic cigarette (EC) refill fluids and EC exhaled aerosol residue on cultured human keratinocytes and MatTek EpiDerm™, a 3D air liquid interface human skin model.

[Scientific Reports] Scientists investigated the chemical components of the F. dubia sap extracted by liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry and its potential use in cosmetics in terms of cellular antioxidation on keratinocytes, phototoxicity, and irritation on 3D skin cell models following standard tests suggested by the Organization for Economic Cooperation and Development.

[International Journal of Pharmaceutics] The obtained nanoparticles have shown low toxicity in keratinocytes, however, higher loadings of cannabidiol or curcumin resulted in increased toxicity. The nanoparticles effectively internalized into keratinocytes, implying their applicability for dermal delivery.

[Nature Protocols] Investigators detailed a six-stage planar differentiation methodology for generating human pluripotent stem cell–derived pancreatic β cells that secreted high amounts of insulin in response to glucose stimulation.

[Cancer Research] Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.

[Cell and Tissue Research] Various factors were precisely modulated to facilitate differentiation of human iPSCs into dental epithelial cells, which are essential for the regeneration of functional teeth.