keratinocytes

[Dermatology] Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.

[Proceedings of the National Academy of Sciences of the United States of America] K17 occurs in the nucleus of human and mouse tumor keratinocytes where it impacts chromatin architecture, gene expression, and cell proliferation. Scientists reported that K17 is induced following DNA damage and promotes keratinocyte survival.

[Communications Biology] The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.

[Particle and Fibre Toxicology] Scientists demonstrated that exposure of human epidermal keratinocytes to Nano-Ni caused increased HIF-1α nuclear accumulation and increased transcription and activity of MMP-2 and MMP-9 and down-regulation of miR-29b and tight junction-associated proteins.

[Molecular Carcinogenesis] Scientists showed that Twist1 had a direct role in maintaining the balance between proliferation and differentiation of keratinocytes and keratinocyte stem/progenitor populations.

[Journal of Investigative Dermatology] Using the Imiquimod psoriasis mouse model, researchers found that MutT homolog 1 (MTH1) inhibition diminished psoriatic histological characteristics and normalized the levels of neutrophils and T cells in skin and skin-draining lymph nodes. The inhibition abolished the expression of Th17-associated cytokines in the skin, which was in line with decreased levels of IL-17-producing γδ T cells in lymph nodes.